Research Catalog

Kallikrein-related peptidases

Title
  1. Kallikrein-related peptidases / editors, Viktor Magdolen [and others].
Published by
  1. Berlin ; Boston : Walter de Gruyter, [2012], ©2012.

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Details

Additional authors
  1. Magdolen, Viktor.
Description
  1. 2 volumes : illustrations (some color); 25 cm
Subject
  1. Neoplasms > genetics
  2. Proteolytic enzymes
  3. Kallikreins > metabolism
  4. Kallikreins > genetics
  5. Kallikrein
  6. Peptide Hydrolases > metabolism
  7. Tumor markers
Contents
  1. Vol. 1. Characterization, regulation, and interactions within the protease web. Genomic structure of the KLK locus -- Single nucleotide polymorphisms in the human KLK locus and their implication in various diseases -- Evolution of Kallikrein-related peptidases -- Structural aspects of Kallikrein-related peptidases -- Molecular recognition properties of Kallikrein-related peptidases on synthetic and endogenous substrates -- Natural, engineered, and synthetic inhibitors of Kallikrein-related peptidases -- Kallikrein-related peptidases as pharmaceutical targets -- Expression of Kallikrein-related peptidases under (patho) physiological conditions -- Kallikrein-related peptidases within the proteolytic web -- Kallikrein-Kinin cascade: bioregulation by human tissue kallikrein 1 (HK1, KLK 1) -- Role of KLK4 in dental enamel formation -- Kallikrein-related peptidases and semen -- Kallikrein-related peptidases and inhibitors of the skin.
  2. Physiological and pathophysiological roles of Kallikrein-related peptidases in the central nervous system -- Kallikrein-related peptidases (KLKS), proteinase-mediated signaling and proteinase-activated receptors (PARS). -- vol. 2. Novel cancer-related biomarkers. Pathophysiology of Kallikrein-related peptidases in lung cancer -- Clinical relevance of Kallikrein-related peptidases in gastric and colorectal cancer -- Pathophysiology of Kallikrein-related peptidases in head and neck cancer -- PSA (prostate-specific antigen) and other Kallikrein-related peptidases in prostate cancer -- Cellular model systems to study the tumor biological role of Kallikrein-related peptidases in ovarian and prostate cancer -- Clinical relevance of Kallikrein-related peptidases in breast cancer -- Clinical relevance of Kallikrein-related peptidases in ovarian cancer -- MicroRNAs : a new control mechanism for Kallikrein-related peptidases in kidney and other cancers -- Genomic instability of the KLK-locus in cancer -- Kallikrein-related peptidases as biomarkers in personalized cancer medicine.
Owning institution
  1. Columbia University Libraries
Bibliography (note)
  1. Includes bibliographical references and index.