Research Catalog

Genetic instability and tumorigenesis

Title
  1. Genetic instability and tumorigenesis / edited by M. B. Kastan.
Published by
  1. Berlin ; New York : Springer, [1997], ©1997.

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Details

Additional authors
  1. Kastan, M. B. (Michael B.)
Description
  1. 180 pages : illustrations; 24 cm.
Summary
  1. This book reviews our current level of understanding of the role of genetic instability in human tumorgenesis. In this incredibly rapidly moving field, discoveries in recent years have elucidated a number of important gene products which control cellular responses to DNA damaging agents, such as DNA repair and cell cycle perturbations. Mutations in these genes appear to be important contributors to the development of a significant percentage of human tumors.
  2. Furthermore, inherited mutations in some of these genes appear to be responsible for a number of familial cancer susceptibility syndromes and studies of the molecular basis for cancer predisposition in these families have provided many insights into the molecular basis of cancer development. Elucidation of these molecular mechanisms also provides a link between exposures to environmental DNA damaging agents and the genetic changes which result in human cancers.
  3. . The discussions cover the gamut from scientific insights into genetic instability learned from simple model systems, such as yeast, to the genes which control these processes in human cells and contribute to human tumor development. Such information is being used to develop approaches to reduce cancer development and to provide more specific targets to improve cancer therapies.
Series statement
  1. Current topics in microbiology and immunology, 0070-217X ; 221
Uniform title
  1. Current topics in microbiology and immunology ; 221.
Subject
  1. Neoplasms > genetics
  2. DNA Damage
  3. DNA Repair
  4. Chromosome Aberrations
Contents
  1. Genetic Instability and Tumorigenesis: Introduction / M. B. Kastan -- Genomic Stability and Instability: A Working Paradigm / K. C. Cheng and L. A. Loeb -- Surveillance and Genome Stability in Budding Yeast: Implications for Mammalian Carcinogenesis / F. Spencer -- Genomic Instability and Its Roles in Neoplasia / T. D. Tlsty -- Role of DNA Excision Repair Gene Defects in the Etiology of Cancer / J. M. Ford and P. C. Hanawalt -- Chromosome Instability Syndromes: Lessons for Carcinogenesis / M. S. Meyn -- Genetic Alterations in Human Tumors / K. R. Cho and L. Hedrick.
Owning institution
  1. Columbia University Libraries
Bibliography (note)
  1. Includes bibliographical references and index.