Research Catalog

Details

Additional authors

1. Cardew, Gail.
2. Chadwick, Derek.
3. Novartis Foundation. http://id.loc.gov/authorities/names/n98048875
4. Symposium on Gramicidin and Related Ion Channel-forming Peptides (1998 : London, England) http://id.loc.gov/authorities/names/n99035498

Description

1. ix, 273 pages : illustrations; 24 cm.

Summary

1. "Gramicidin channels have been studied intensively for more than 25 years as model transport systems for large protein ion channels, high resolution structural information on which is difficult to glean. This book includes contributions from virtually all the major 'players' in the gramicidin sphere, and is the only compilation of work in this field.
2. It discusses crystallographic, spectroscopic, electrophysiological and computational studies, especially in the light of the recent availability of high resolution structural data; and it compares these with insights derived from larger systems. As well as drawing together much new and exciting work in this area; it also provides pointers to promising new research directions."--BOOK JACKET.

Series statement

1. Novartis Foundation symposium ; 225

Uniform title

1. Novartis Foundation symposium ; 225.

Subject

1. Ionophores
2. Ionophores > Congresses
3. Ion Channels
4. Gramicidin
5. Congress
6. Gramicidins > Congresses
7. Ion channels > Congresses

Genre/Form

1. Congress.

Contents

1. Introduction: gramicidin, a model ion channel / B. A. Wallace -- Correlations of structure, dynamics and function in the gramicidin channel by solid-state NMR spectroscopy / T. A. Cross, F. Tian and M. Cotten / [et al.] -- X-ray crystallographic structures of gramicidin and their relation to the Streptomyces lividans potassium channel structure / B. A. Wallace -- General discussion I: The effects of ion binding -- Design and characterization of gramicidin channels with side chain or backbone mutations / R. E. Koeppe II, D. V. Greathouse and L. L. Providence / [et al.] -- Engineering charge selectivity in alamethicin channels / G. A. Woolley, A. V. Starostin and R. Butan / [et al.] -- Lorentzian noise in single gramicidin A channel formamidinium currents / T. G. Fairbanks, C. L. Andrus and D. D. Busath -- Can we use rare constants and state models to describe ion transport through gramicidin channels? / S. B. Hladky --
2. The binding site of sodium in the gramicidin A channel / B. Roux and T. B. Woolf -- The mechanism of channel formation by alamethicin as viewed by molecular dynamics simulations / M. S. P. Sansom, D. P. Tieleman and H. J. C. Berendsen -- General discussion II: The Poisson-Nernst-Plancke model -- General discussion II: The biological activities of gramicidin D -- Ionic interactions in multiply occupied channels / V. L. Dorman, S. Garofoli and P. C. Jordan -- Peptide influences on lipids / J. A. Killian, S. Morein and P. C. A. van der Wel / [et al.] -- Peptide - lipid interactions and mechanisms of antimicrobial peptides / H. W. Huang -- Folding patterns of membrane proteins: diversity and the limitations of their prediction / J. P. Rosenbusch -- Molecular basis of the charge selectivity of nicotinic acetylcholine receptor and related ligand-gated ion channels / P.-J. Corringer, S. Bertrand and J.-L. Galzi / [et al.] --
3. The gramicidin-based biosensor: a functioning nano-machine / B. A. Cornell, V. B. L. Braach-Maksvytis and L. G. King / [et al.] -- Final general discussion: Protons -- Summary: What we have learned about gramicidin and other ion channels.

Owning institution

1. Columbia University Libraries

Bibliography (note)

1. Includes bibliographical references and index.