Genetics of infectious disease susceptibility
- Title
- Genetics of infectious disease susceptibility / Tjeerd G. Kimman.
- Published by
- Boston : Kluwer Academic Publishers, c2001.
- Author
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Status | Format | Access | Call number | Item location |
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Status | FormatText | AccessUse in library | Call numberRC112 .K563 2001 | Item locationOff-site |
Details
- Description
- 247 p. : ill.; 25 cm.
- Summary
- "Infectious diseases have been major evolutionary forces throughout history and they have thus shaped our body and its defence mechanisms. Nowadays they still kill at least 13 million people every year, mostly in the developing world, and many more are infected.".
- "Yet, we probably all remember infections spreading in households, classrooms, or countries, wondering why some get sick while others remained healthy. The purpose of this text is to promote and exploit that curiosity. It provides an overview of host genetic factors that provide complete or partial resistance to infection, that influence the clinical outcome of infection, or that give the capacity to remain healthy during infection.".
- "Progress in the molecular analysis of genetic susceptibility to human and animal infectious diseases has been very rapid over the last few years. Several genes involved in resistance to HIV/AIDS, tuberculosis, malaria, viral hepatitis, herpesvirus infections, prion diseases, and several others have now been identified, and their functions have partly or completely been elucidated.".
- "This book covers the most recent advances in the field and explores how progress in knowing the genetic basis of infectious diseases could lead to new insights into understanding and combating them."--BOOK JACKET.
- Subject
- Contents
- Pt. I. General principles and methods. Ch. 1. What is the contribution of host genetics to infectious disease? Ch. 2. Genetic diversity and infectious disease. Ch. 3. Co-evolutionary forces and balanced pathogenicity. Ch. 4. Mapping susceptibility loci. Ch. 5. The use of animal models and comparative genomics. Ch. 6. How to identify relevant candidate genes? -- Pt. II. Genes and gene functions influencing susceptibility to infectious disease. Ch. 7. Genes involved in attachment and entry of micro-organisms into the body. Ch. 8. Genes involved in innate immunity. Ch. 9. Genes involved in antigen processing and presentation. Ch. 10. Genes regulating immune and inflammatory responses. Ch. 11. Genes influencing lymphocyte function. Ch. 12. Genes involved in accessory effector cell function. Ch. 13. Genes involved in tissue function and integrity. Ch. 14. Infectious diseases, blood groups, and secretor status --
- Pt. III. Genetics of specific infectious and multicausal diseases. Ch. 15. Helicobacter pylori. Ch. 16. Tuberculosis. Ch. 17. Bacterial meningitis and sepsis. Ch. 18. Resistance to influenza virus. Ch. 19. Resistance to HIV/AIDS and other retroviruses. Ch. 20. Genetic factors influencing the outcome of viral hepatitis. Ch. 21. Resistance to malaria. Ch. 22. Trypanotolerance. Ch. 23. Post infection complications: the examples of reactive arthritis and Guillain-Barre syndrome. Ch. 24. Host genes, infection, and cancer: the example of cervical cancer. Ch. 25. Genetic predisposition to transmissible spongiform encephalopathies -- Pt. IV. Application of infectious disease genetics in human and veterinary medicine. Ch. 26. Use of genetic information in preventive medicine, public health, and patient treatment. Ch. 27. Pharmacogenetics in the treatment of infectious disease. Ch. 28. Genetics and the response to vaccination.
- Ch. 29. Improving genetic disease resistance in farm animals. Ch. 30. Infectious disease genetics in laboratory animal science.
- Owning institution
- Columbia University Libraries
- Bibliography (note)
- Includes bibliographical references and index.