Research Catalog

Radiotracers in drug development

Title
  1. Radiotracers in drug development / Graham Lappin, Simon Temple.
Published by
  1. Boca Raton : CRC/Taylor & Francis, 2006.
Author
  1. Lappin, Graham, PhD.

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Details

Additional authors
  1. Temple, Simon.
Description
  1. 300 pages, 5 unnumbered pages of plates : illustrations (some color); 25 cm
Summary
  1. "Although there are numerous books on drug metabolism, Radiotracers in Drug Development is unique in explaining how radiotracers are used to elucidate a drug's absorption, distribution, metabolism, and excretion (ADME). Covering traditional and recent technologies and applications, the book takes a strong industrial approach, discussing the basics of scintillation counting and untangling the various data processing methods often specific to individual manufacturers." "A reference and training aid essential for every drug metabolism department or drug metabolism research team, the book provides insight into the use and practice of ADME in a way that is both instructive and practical. Moving easily across the boundaries of biology, chemistry, and physics, this resource covers the how-tos of employing radiotracers in drug development. It provides detailed information on how the science is relevant to the registration process."--BOOK JACKET.
Subject
  1. Radioactive tracers
  2. Médicaments > Développement > Méthodologie
  3. Drug Industry > methods
  4. Pharmacokinetics
  5. Scintillation Counting > methods
  6. Radioactive Tracers
  7. Traceurs radioactifs
  8. Drug development > Methodology
Contents
  1. ch. 1. Radiotracers and drug registration / Graham Lappin -- ch. 2. Radioactivity and radiotracers / Graham Lappin -- ch. 3. The study of drug metabolism using radiotracers / Graham Lappin -- ch. 4. DNA binding, isotope dilution, and other uses of radiotracers / Graham Lappin -- ch. 5. Quantitative whole-body autoradiography (QWBA) / Brian Whitby -- ch. 6. Scintillation counting / Simon Temple -- ch. 7. Statistics in liquid scintillation counting / Simon Temple -- ch. 8. Instrumentation for detection of radioactivity / Simon Temple -- ch. 9. Sample preparation for liquid scintillation counting / Simon Temple -- Ch. 10. Biomedical accelerator mass spectrometry / Graham Lappin -- ch. 11. Positron emission tomography / Barbara S. Koetz and Patricia M. Price -- ch. 12. Gamma scintigraphy and SPECT / Stephen P. Newman and Gary R. Pitcairn.
Owning institution
  1. Columbia University Libraries
Bibliography (note)
  1. Includes bibliographical references and index.