Research Catalog

Comparative QSAR / edited by James Devillers.

Title
  1. Comparative QSAR / edited by James Devillers.
Published by
  1. Washington, D.C. : Taylor & Francis, c1998.

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Details

Additional authors
  1. Devillers, James, 1956-
Description
  1. ix, 371 p. : ill.; 24 cm.
Summary
  1. As the 21st century approaches, there is little doubt that the tools and resources are available to unlock all the secrets of Quantitative Structure-Activity Relationships (QSAR) in order to design more efficient drugs and safer chemicals. The comparison QSAR models provide are a key to reach a deep understanding of the foundation and a better optimisation of the use of these statistical tools. Seeking out the similarities and differences among QSAR Models allows the user to estimate their simulation performances, find chemo-taxonomical links, and uncover In vivo/In Vitro relationships. The purpose of this book is to highlight the multifaceted aspect of the term "comparative QSAR" by bringing together QSAR experts of various origins and allowing them to offer their views on this diverse subject.
Alternative title
  1. Comparative quantitative structure-activity relationships
Subject
  1. Drug Design
  2. Models, Theoretical
  3. Models, Molecular
  4. Biochemistry
  5. Structure-Activity Relationship
  6. QSAR (Biochemistry)
Contents
  1. Comparison of fish bioconcentration models / J. Devillers [and others] -- QSAR in aquatic toxicology: a mechanism of action approach comparing toxic potency to Pimephales promelas, Tetrahymena pyriformis and Vibrio fischeri / T.W. Schultz, G.D. Sinks and A.P. Bearden -- Comparative QSAR and 3-D-QSAR analysis of the mutagenicity of nitroaromatic compounds / R.L. Compadre, C. Byrd and C.M. Compadre -- Some novel approaches to modeling transdermal penetration and reactivity with epidermal proteins / P.S. Magee -- Contribution of structure-odor relationships to the elucidation of the origin of musk fragrance activity / D. Zakarya and M. Chastrette -- QSAR analysis of protoporphyrinogen oxidase inhibitors / K.N. Reddy, F.E. Dayan and S.O. Duke -- Comparative quantitative structure activity relationships (QSAR) of the inhibition of dihydrofolate reductase / C.D. Selassie and T.E. Klein -- Generalized approach to comparative QSAR / C. Hansch, H. Gao and D. Hoekman.
Owning institution
  1. Harvard Library
Bibliography (note)
  1. Includes bibliographical references and index.
Processing action (note)
  1. committed to retain