Research Catalog

Details

Additional authors

1. Wickstrom, Eric

Description

1. 427 p. : ill.; 24 cm.

Summary

1. Presents illustrative examples of disease in which gene-based interventions are plausible. Includes case studies of current research using both synthetic oligonucleotides and biological vectors. For pharmacologists, biochemists, pathologists, and medical and graduate students.

Subject

1. Clinical trials
2. Genetic vectors > Therapeutic use > Testing
3. Antisense DNA > Therapeutic use > Testing
4. Gene therapy > Testing
5. Genetic Therapy
6. DNA, Antisense
7. Genetic Vectors
8. Clinical Trials as Topic

Contents

1. Foreword: Genetic Therapy in the 21st Century / O. Michael Colvin -- Preface: From Theory to Practice in Thirty Years / Eric Wickstrom -- 1. A Brief History of Genetic Therapy: Gene Therapy, Antisense Technology, and Genomics / James W. Hawkins -- 2. Preclinical Development of Antisense Oligonucleotide Therapeutics for Cancer: Regulatory Aspects / Chang-Ho Ahn and Joseph J. DeGeorge -- 3. Commercial Scale Manufacturing of Oligonucleotides Under Good Manufacturing Practices / Jose E. Gonzalez, Richard G. Einig and Patricia Puma -- 4. The Regulatory Process and Gene Therapy / Suzanne L. Epstein -- 5. Production of Clinical Lots of Gene Therapy Vectors Using Good Manufacturing Practice: Experience in a University Setting / Alan R. Davis and Colleen Baker -- 6. Gene Therapy Clinical Trials for Adenosine Deaminase Deficiency/Severe Combined Immunodeficiency / Erlinda M. Gordon and W. French Anderson -- 7. Development of an Oligodeoxynucleotide Pharmaceutical for the Treatment of Human Leukemia / Alan M. Gewirtz and Deborah Lee Sokol -- 8. Clinical Trials with Anti-p53 DNA, OL(1)p53, in Patients with Acute Myelogenous Leukemia and Myelodysplastic Syndrome / Patrick L. Iversen -- 9. Human Bcl-2 Antisense Therapy for Lymphomas / Finbarr E. Cotter, Andrew Webb and Paul Clarke -- 10. Retroviral Gene Transfer in Autologous Bone Marrow and Stem Cell Transplantation / Rafat Abonour and Kenneth Cornetta
2. 11. Adenoviral Gene Transfer of the Herpes Virus Thymidine Kinase Gene for Treating Gliomas / Jane B. Alavi, Jason G. Smith and Stephen L. Eck -- 12. Distribution and Toxicity of Retroviral Vectors After Intracavitary Delivery in Mouse and Man / Patrice S. Obermiller, Anne M. Pilaro and Carlos L. Arteaga -- 13. Clinical and Immunologic Responses to Gene Transfer of an Allogeneic Major Histocompatibility Complex Antigen / Alison T. Stopeck and Evan M. Hersh -- 14. Defective Tumor Suppressor Gene Replacement and Oncogene Inactivation for the Treatment of Cancer / Jack Roth -- 15. The Molecular Basis of Bladder Cancer and Prospects for Gene Therapy Using Hammerhead Ribozymes / Eric J. Small, Mohammed Kashani-Sabet and David Y. Bouffard -- 16. In Situ Gene Insertion for Immunotherapy Using Vaccinia Virus Vectors / Edmund C. Lattime, Laurence C. Eisenlohr and Michael J. Mastrangelo -- 17. Antisense Oligonucleotide-Based Therapy for HIV-1 Infection from Laboratory to Clinical Trials / Sudhir Agrawal -- 18. Treatment of Retinitis Induced by Cytomegalovirus Using Intravitreal Fomivirsen (Isis 2922) / Stanley T. Crooke -- 19. Synthetic DNA-Based Compounds for the Prevention of Coronary Restenosis: Current Status and Future Challenges / Andrew Zalewski, Yi Shi and John D. Mannion -- 20. Prevention of Restenosis by Gene Targeting / Michael J. Mann, Heiko E. Von der Leyen and Victor J. Dzau.

Owning institution

1. Harvard Library

Bibliography (note)

1. Includes bibliographical references and index.