Research Catalog

Details

Additional authors

1. Willette, Robert E.
2. Barnett, Gene.
3. United States. Department of Health and Human Services.

Description

1. viii, 276 pages : illustrations; 23 cm.

Series statement

1. DHHS publication ; no. (ADM) 81-102
2. NIDA research monograph ; 28

Uniform title

1. DHHS publication ; no. (ADM) 81-102.
2. NIDA research monograph ; 28.

Subject

1. Naltrexone > Physiological effect > Research > United States
2. Narcotic antagonists > Physiological effect
3. Drugs > Controlled release
4. Heroin abuse > Treatment > Research > United States
5. Naloxone
6. Narcotic antagonists
7. Naltrexone > Physiological effect
8. Naloxone
9. Narcotic Antagonists
10. Delayed-Action Preparations
11. Narcotic antagonists
12. Drugs > Controlled release
13. Heroin abuse > Treatment
14. Narcotic antagonists > Physiological effect
15. Farmacologia

Contents

1. Part I. Introduction and Overview -- Historical perspective on the chemistry and development of Naltrexone / Sydney Archer -- Treatment of heroin-dependent persons with antagonists: current status / Pierre Renault -- Part II. Analytical Methods -- An electron-capture gas chromatographic assay for Naltrexone in biological fluids / R.H. Reuning, S.B. Ashcraft, and B.E. Morrison -- Quantitative determination of Naltrexone, 6 Beta-Naltrexol and 2-Hydroxy-3-methoxy-6beta-naltrexol (HMN) in human plasma, red blood cells, saliva, and urine by gas liquid chromatography / Karl Verebey -- Analytical methods for quantitative and qualitative analysis of Naltrexone and metabolites in biological fluids / Monroe E. Wall and Dolores R. Brine -- Part III. Pharmacology -- Background on animal testing in the drug delivery systems program / William L. Dewey -- Pharmacological evaluation of narcotic antagonist delivery systems in Rhesus monkeys / Stephen E. Harrigan and David A. Downs -- A comparative study of the oral, intravenous, and subcutaneous administration of ³H Naltrexone to normal male volunteers / Mario Perez-Reyes and Monroe E. Wall -- Part IV. Metabolism -- The metabolism of Naltrexone in man / Monroe E. Wall, Dolores R. Brine, and Mario Perez-Reyes -- Current status of preclinical research on disposition, pharmacokinetics, and metabolism of Naltrexone / Anand L. Misra -- The clinical pharmacology of Naltrexone: pharmacology and pharmacodynamics / Karl Vereby -- Part V. Pharmacokinetics -- Overview of human pharmacokinetics of Naltrexone / Vojtech Ličko -- Pharmacokinetic quantitation of Naltrexone release from several sustained-release delivery systems / R.H. Reuning, S.H.T. Liao, and A.E. Staubus -- Part VI. Sustained-release systems -- A review of parenteral sustained-release Naltrexone systems / James L. Olsen and Fred A. Kincl -- Development of drug delivery systems for use in treatment of narcotic addiction / A. Carl Sharon and Donald L. Wise -- Use of synthetic polypeptides in the preparation of biodegradable delivery systems for narcotic antagonists / Kenneth R. Sidman, Arthur D. Schwope, William D. Steber, and Stephen E. Rudolph -- Biodegradable drug delivery systems based on aliphatic polyesters: application to contraceptives and narcotic antagonists / Colin G. Pitt, Thomas A. Marks, and Anton Schindler -- An improved long-acting delivery system for narcotic antagonists / Anand L. Misra and Ronald B. Pontani -- Solid solutions as long-acting Naltrexone delivery systems / James L. Olsen.

Owning institution

1. Princeton University Library

Note

1. "Based on papers presented at a technical review on the clinical pharmacochemistry of naltrexone, held at Parklawn Building, Rockville, Maryland, on May 30 and 31, 1979"--P. iv.
2. S/N 017-024-01081-2
3. Item 831-C-8

Bibliography (note)

1. Includes bibliographical references.