Research Catalog

Details

Additional authors

1. Maxwell, Anthony.

Description

1. xii, 114 pages : illustrations (some color); 23 cm

Summary

1. The existence and biological importance of deformations of the double helix structure of DNA have become known and are generally termed "topology". This book explains the concepts of DNA topology and discusses their relevance to biology.

Series statement

1. In focus

Uniform title

1. In focus (Oxford, England)

Subject

1. Design Network Switzerland
2. DNA > Conformation
3. DNA > physiology
4. DNA > Conformation
5. Konformation
6. DNS
7. DNA
8. Structuur
9. Dna (estrutura)
10. ADN > Relations structure-activité
11. ADN > Conformation

Contents

1. DNA structure -- Watson-Crick model -- B-form DNA -- A-form DNA -- Z-form DNA -- Alternative DNA structures -- Cruciforms and Holliday junctions -- H-DNA -- Intrinsic curvature and DNA bending -- Intrinsic curvature -- DNA flexibility -- DNA supercoiling -- Historical perspective -- Closed-circular DNA and supercoiling -- Quantitative measure of DNA supercoiling -- Linking number -- Supercoiling, linking difference, and specific linking difference -- Geometric properties of closed-circular DNA -- Twist and writhe -- Interconversion of twist and writhe -- Nomenclature -- Topology and geometry of real DNA -- Agarose gel electrophoresis of plasmids -- Relaxation with topoisomerases -- Effect of intercalators -- Effect of protein binding -- Thermodynamics of DNA supercoiling -- Ethidium bromide titration -- Gaussian distribution of topoisomers -- Effect of DNA circle size -- Supercoiling in small DNA circles -- Biological effects of supercoiling free energy -- DNA on surfaces -- Helical repeat of DNA -- Surface linking treatment -- DNA winding number -- Surface linking number -- Interwound supercoiled DNA.
2. (cont) Nucleosome -- Linking difference and the linking number paradox -- Early resolution of the linking number paradox -- Helical repeat at the nucleosome surface -- Measurements of hs for the nucleosome -- Topology and geometry of DNA in the nucleosome -- Knots and catenanes -- Knots -- Occcurrence of knots -- Description of knots -- Catenanes -- Occurrence of catenanes -- Description of catenanes -- Knots and catenanes as probes of DNA: protein interactions -- DNA topoisomerases -- Reactions of topoisomerases -- Mechanisms of topoisomerases -- Topoisomerases as drug targets -- Biological role of topoisomerases -- Biological consequences of DNA topology -- Introduction: the ubiquity of DNA supercoiling -- General biological consequences of negative supercoiling -- Genome organization -- Eukaryotes -- Prokaryotes -- Transcription: the twin supercoiled domain model -- New role for topoisomerases -- Control of gene expression -- RNA polymerase binding -- Transcriptional regulatory proteins -- Replication -- Replication initiation -- Replication elongation -- Termination of replication.
3. (cont) Recombination -- Bacteriophage [gamma] Int protein -- Resolvase.

Owning institution

1. Princeton University Library

Note

1. Errata slip inserted.

Bibliography (note)

1. Includes bibliographical references and index.