Research Catalog

Details

Additional authors

1. Chadwick, Derek.
2. Marsh, Joan.
3. Goode, Jamie.
4. Ciba Foundation.

Description

1. ix, 287 pages : illustrations (some color); 24 cm.

Summary

1. The survival of an organism depends largely on its ability to monitor its environment constantly and accurately. To do this, organisms have evolved a wide range of sensory systems to detect, transduce and evaluate relevant environmental signals. Smell and taste are two primary neurosensory systems that animals use to assess the external chemical environment. This monitoring is a complex operation: an organism must be capable of resolving not only a single odorant or taste stimulant from a heterogeneous mix of chemicals, but also concentration differences and their temporal variation. The systems that have developed to fulfil these tasks appear to be functionally similar in organisms as diverse as Drosophila and humans. The contemporary techniques of molecular biology, microprotein sequencing, immunohistochemistry and patch-clamp electrophysiology have permitted the study of the molecular basis of chemosensory transduction. Consequently, characterization of the biochemical and molecular mechanisms associated with smell and taste is now experiencing an expansion that would have been unthinkable only a few years ago. Of particular interest has been the recent cloning of olfactory receptor genes: the expression patterns of some of these are described in this book. Other important work reported here includes the identification of olfactory binding proteins, genetic analysis in Drosophila and Caenorhabditis elegans, the G protein-mediated activation of second messenger pathways, and the role of ion channels, perireceptor events and mucus proteins in chemosensory transduction. The book contains contributions from many of the leading scientists working on varied aspects of the chemical senses, with discussion of their recent results and the most important questions that remain to be addressed. This book includes the latest information from the field and will be of interest to both those working on chemosensory transduction and those interested in signal transduction in general.

Series statement

1. Ciba Foundation symposium ; 179

Uniform title

1. Ciba Foundation symposium ; 179.

Subject

1. Smell > Molecular aspects > Congresses
2. Taste > Molecular aspects > Congresses
3. Cellular signal transduction > Congresses
4. Second messengers (Biochemistry) > Congresses
5. G proteins > Congresses
6. Cellular signal transduction
7. Chemoreceptor Cells > physiology
8. GTP-Binding Proteins > physiology
9. Signal Transduction
10. Smell > physiology
11. Taste > physiology
12. G proteins
13. Second messengers (Biochemistry)
14. Smell > Molecular aspects
15. Taste > Molecular aspects
16. Communication cellulaire > Congrès comme sujet
17. Protéines G > congrès
18. Goût > Congrès comme sujet
19. Systèmes de seconds messagers > Congrès comme sujet
20. Transduction du signal > Congrès comme sujet
21. Odorat > Congrès comme sujet
22. Biochemie
23. Geruchssinn
24. Geschmackssinn
25. Molekularbiologie
26. Signaltransduktion
27. Smaakzin
28. Reukzin
29. Signaalverwerking
30. Fisiologia animal (congressos)
31. Biologia molecular e macromolecular
32. Fisiologia humana
33. Odorat > Congrès
34. Goût > Congrès
35. Messagers secondaires (biochimie) > Congrès
36. Protéines G > Congrès
37. Transduction du signal cellulaire > Congrès

Genre/Form

1. Congress
2. Conference papers and proceedings.
3. Actes de congrès.

Contents

1. From genotype to olfactory neuron phenotype: the role of the Olf-1-binding site / F.L. Margolis [and others] -- Mucous domains: microchemical heterogeneity in the mucociliary complex of the olfactory epithelium / T.V. Getchell, Z. Su and M.L. Getchell -- Receptor diversity and spatial patterning in the mammalian olfactory system / L.B. Buck -- Molecular mechanisms of olfactory neuronal gene regulation / M.M. Wang and R.R. Reed -- New tool for investigating G protein-coupled receptors / M.R. Lerner [and others] -- Second messenger signalling in olfaction / H. Breer -- Membrane currents and mechanisms of olfactory transduction / S. Firestein and F. Zufall -- Olfactory receptors: transduction, diversity, human psychophysics and genome analysis / D. Lancet [and others] -- Molecular genetics of Drosophila olfaction / J. Carlson -- Perireceptor events in taste / H. Schmale [and others] -- Gustducin and transducin: a tale of two G proteins / S.K. McLaughlin [and others] -- Role of apical ion channels in sour taste transduction / S.C. Kinnamon -- Ion pathways in the taste bud and their significance for transduction / J.A. DeSimone, Q. Ye and G.E. Heck -- Cellular and genetic basis of olfactory responses in Caenorhabditis elegans / P. Sengupta [and others] -- Genetic and pathological taste variation: what can we learn from animal models and human disease? / L.M. Bartoshuk -- Summing-up / F.L. Margolis.

Owning institution

1. Princeton University Library

Note

1. "A Wiley-Interscience publication."
2. Symposium on the Molecular Basis of Smell and Taste Transduction, held at the Ciba Foundation, London, Feb. 1993.

Bibliography (note)

1. Includes bibliographical references and indexes.