Research Catalog

Details

Additional authors

1. Siemen, D. (Detlef), 1950-
2. Hescheler, J. K.-J. (Jürgen Karl-Josef), 1959-

Description

1. xiii, 316 pages : illustrations; 24 cm.

Summary

1. In 1981, Neher and Sakmann published a pioneering paper describing the patch clamp method for measuring the currents flowing through individual ion channels. Apart from channels which are selective for a single species of ion, numerous "nonselective channels" have been found since then, which are activated by various agonists and differ in selectivity and amino acid sequence. Today it is widely acknowledged that these channels belong to the most important component of the cell membrane and fulfil a wide spectrum of different functions. Nonselective Cation Channels is the first book to report on the immense variety and diversity of nonspecific ion channels, ranging from the nicotinic acetylcholine receptor to the gap junction channel. Written by recognized international experts, its coverage also includes the role of nonselective cation channels in cardiac and smooth muscle cell functions, and their importance in human platelets and endothelial cells. Sections on receptor-activated and mechanically sensitive cation channels are also included. Primarily intended for scientists in basic biomedical and biological research, including physiology/electrophysiology, neurophysiology, pharmacology, toxicology, biochemistry, biophysics, neurobiology, cell biology, molecular biology and zoology, this book will also be of interest to clinicians as well as graduate and postgraduate students.

Series statement

1. EXS ; 66

Uniform title

1. EXS ; 66.

Subject

1. Ion channels
2. Cations > Physiological transport
3. Cations > metabolism
4. Cations > pharmacology
5. Ion Channels > drug effects
6. Ion Channels > physiology
7. Ion Channels
8. Ionenkanalen
9. Kationen
10. Cations

Contents

1. Nonselective cation channels / D. Siemen -- Nonselective cation channels: physiological and pharmacological modulations of channel activity / J. Hescheler and G. Schultz -- Receptor-activated nonselective cation channels -- Structure, diversity and ionic permeability of neuronal and muscle acetylcholine receptors / J.A. Dani -- AMPA-type glutamate receptors: nonselective cationic channels mediating fast excitatory transmission in the CNS / P. Jonas -- Mechanically sensitive cation channels -- Mechanically sensitive, nonselective cation channels / X.-C. Yang and F. Sachs -- Stretch-activated nonselective cation channels in urinary bladder myocytes: importance for pacemaker potentials and myogenic response / M.-C. Wellner and G. Isenberg -- Mechanosensitive nonselective cation channels in the antiluminal membrane of cerebral capillaries (blood-brain barrier) / R. Popp, J. Hoyer and H. Gogelein -- Gap junction channels -- Gap junction channel / R. Dermietzel -- Cyclic nucleotide-activated nonselective cation channels -- Cyclic nucleotide-gated nonselective cation channels: a multifunctional gene family / C.J. Barnstable.
2. (cont) Cyclic AMP-gated cation channels of olfactory receptor neurons / F. Zufall -- Renal epithelial cells show nonselective cation channel activity and express a gene related to the cGMP-gated photoreceptor channel / C. Korbmacher and C.J. Barnstable -- Ciliary cation conductances in olfactory receptor cells of the clawed toad Xenopus laevis / D. Schild -- Nonselective cation channels activated by intracellular calcium -- Control of cell function by neuronal calcium-activated nonselective (CAN) cation channels / L.D. Partridge and D. Swandulla -- Nonselective cation channels in exocrine gland cells / P. Thorn and O.H. Petersen -- Nonselective cation channels in brown and white fat cells / A. Koivisto [and others] -- Inhibitors of nonselective cation channels in cells of the blood-brain barrier / R. Popp [and others] -- Nonselective cation channels in cells of the crypt-base of rat distal colon / C. Siemer and H. Gogelein -- Nonselective cation channels as regulatory components of cells from various tissues -- Poorly selective cation channels in apical membranes of epithelia / W. Van Driessche [and others].
3. (cont) Nonselective cation channels in cardiac and smooth muscle cells / G. Isenberg -- Physiology of muscarinic receptor-operated nonselective cation channels in guinea-pig ileal smooth muscle / R. Inoue and S. Chen -- Nonselective ion pathways in human endothelial cells / B. Nilius [and others] -- Properties and regulation of human platelet cation channels / J. Geiger and U. Walter -- Role of a PDGF-activated nonselective cation channel in the proliferative response / J.J. Gargus, A.M. Frace and F. Jung -- Cation channels in oocytes and early states of development: a novel type of nonselective cation channel activated by adrenaline in a clonal mesoderm-like cell line (MES-1) / T. Kleppisch, A.M. Wobus and J. Hescheler -- Slowly-activating cation channels in the vacuolar membrane of plants / T. Weiser.

Owning institution

1. Princeton University Library

Bibliography (note)

1. Includes bibliographical references and index.